Table 1 Genes showing crosstalk between the β 2 -adrenergic and TNF-α triggered pathways
Fold induction versus vehicle | Pvalue | |||
|---|---|---|---|---|
GENE | ISO | TNF | TNF + iso | ISO + TNF vs. TNF |
A20 | 1.11 | 25.70 | 70.24 | 0.03 |
ABCB1 | -1.09 | 18.22 | 17.10 | 0.694 |
C3 | -1.10 | 22.69 | 8.85 | 0.113 |
CCL5 | 1.84 | 89.53 | 49.39 | 0.602 |
CSF2 | -1.92 | 55.06 | 17.88 | 0.069 |
CXCL2 | 5.57 | 10.34 | 29.12 | 0.053 |
CXCL3 | 3.17 | 13.08 | 35.17 | 0.097 |
ICAM-1 | -1.03 | 39.16 | 16.01 | 0.146 |
IL-6 | 2.18 | 1.66 | 253.07 | 0.002 |
LEF1 | -4.75 | -52.41 | 1.09 | 0.015 |
PSMB9 | 1.03 | 12.72 | 8.73 | 0.244 |
PTX3 | -1.37 | 21.11 | 14.45 | 0.220 |
VCAM-1 | 1.07 | 445.48 | 153.39 | 0.510 |
BCL3 | 1.19 | 2.70 | 2.92 | 0.265 |
CSF1 | -1.40 | 4.38 | 4.48 | 0.262 |
FAS | 1.18 | 3.80 | 5.99 | 0.173 |
IL15 | 1.74 | 6.20 | 5.61 | 0.289 |
IL1RN | 1.79 | 2.44 | 3.01 | 0.237 |
PLAU | -2.69 | 12.97 | 16.09 | 0.108 |
TAP1 | 1.25 | 18.71 | 19.28 | 0.245 |
TRAF1 | 2.19 | 6.37 | 4.79 | 0.424 |