Figure 1

CX3CR1 deficiency attenuates infarct volume and neurological deficit after middle cerebral artery occlusion. (A) Infarct volume was assessed by T2-weighted images at 24 and 72 hours post-ischemia. (B) Quantification of T2 images shows that the infarct volume was attenuated by CX3CR1 deficiency 72 hours after middle cerebral artery occlusion (MCAO). P < 0.0001 for genotype, P = 0.0194 for time point, and P = 0.0011 for interaction by two-way analysis of variance. **P < 0.01 by Bonferroni post-hoc tests. (C) Clinical assessment demonstrated that CX3CR1^-/- mice have better neurological deficit scores than wild-type (WT) mice 72 hours after MCAO. P = 0.0049 for genotype, P = 0.0262 for time point, and P = 0.0062 for interaction by two-way analysis of variance. *P < 0.05 by Bonferroni post-hoc tests. n = 6 per group.