Ilantide attenuates the severity of arthritis in animals with collagen-induced arthritis. (A) Collagen-induced arthritis was induced by an intradermal injection of 250 μg of collagen II emulsified in complete Freund’s adjuvant (125 μg M. tuberculosis). On day postimmunization 8 (dpi 8), before the onset of clinical signs, all of the animals were randomly divided into two groups and subcutaneously dosed daily for 8 days (dpi 8 to 15) with 10 mg/kg Ilantide-t (n = 17) or 1 ml/kg phosphate-buffered saline vehicle (n = 16). (B) To evaluate cumulative clinical scores during the entire treatment period, the values are expressed as the area under the curve for each group during dpi 10 to 15 with the baseline set at dpi 8. The data are expressed as mean ± SEM. *P < 0.05 by unpaired t-test.