Figure 8From: Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis The TSPO ligand XBD173 reduces the number of alerted amoeboid retinal microglia ex vivo . (A-D) Representative GFP images of the retinal microglia network in explanted mouse retinas treated for 24 hours with vehicle (A), 20 μM XBD173 (B), 1 μg/ml LPS + vehicle (C) and 1 μg/ml LPS + 20 μM XBD173 (D). (E) Quantification of ramified and amoeboid microglial cells in 10 independent image areas of two individual flat mounts (mean ± SEM). **P <0.01 for amoeboid cells in LPS versus control explants; ***P <0.0001, for amoeboid cells in XBD173 + LPS versus LPS-treated explants. GFP, green fluorescent protein; LPS, lipopolysaccharide; TSPO, translocator protein (18 kDa).Back to article page