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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation

Figure 6

Effect of stress and lipopolysaccharide on inhibitor of nuclear factor κB kinase, subunit β, and Iba-1 in the substantia nigra. Iba-1 immunofluorescence (A), (D) and (G) and inhibitor of nuclear factor κB kinase, subunit β (IKKβ), immunofluorescence (B), (E) and (H) show robust induction of IKKβ in Iba-1-labelled microglial cells in the merged images (C), (F) and (I). Images (A), (B) and (C) were taken of an animal injected with lipopolysaccharide (LPS; L). Images (D) through (F) were taken of a stressed animal injected with LPS (SL). Images (G), (H) and (I) are high-magnification photomicrographs showing one representative cell. Scale bars: (A) through (F), 200 μm; (G) through (I), 25 μm. Arrows indicate colocalizing cells.

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