Apocynin treatment selectively inhibits astrocyte activation after sepsis. Effects of sepsis induction on OX42-like immunoreactivity in CA1 (A), CA3 (B) and DG (C) and GFAP immunoreactivity in CA1 (D), CA3 (E) and DG (F) in the hippocampi of animals allowed to survive for five days after sepsis onset. The graphs depict optical density data. In A, B and C, the statistical significance is expressed as: ***P < 0.001 and **P < 0.01 versus sham. In D, **P < 0.01 versus sham and **P < 0.01 versus sepsis. In E and F, ***P < 0.001 versus sham and ***P < 0.001 versus sepsis. n = 5 to 6 in each case. DG: dentate gyrus.