Systemic inflammation induced by sepsis is not affected by the pharmacological inhibition of Nox2. Effects of sepsis induction on MCP-1 and IL-1 levels in the plasma and peritoneal fluid of WT animals treated with apocynin. Mice were allowed to survive for six hours after sepsis onset. All concentrations were expressed in pg/ml. The statistical significance is expressed as: ***P < 0.001; n = 6 to 10 for each experimental group tested.