Skip to main content
Figure 1 | Journal of Neuroinflammation

Figure 1

From: NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice

Figure 1

RM-1 cell inoculation induces BCP. (A) The animals’ body weight was increased in 21 days in both sham-control and tumor-inoculated animals. (B) Radiography shows cortical bone damage in the distal one-third of the right femur (arrows) at 21 days after inoculation. (C, D) Behavioral tests show that mice displayed both heat hyperalgesia and mechanical allodynia in the ipsilateral paw after RM-1 cell inoculation. The PWL decreased at 7 days and maintained for more than 21 days (C). The PWT progressively decreased from 7 days to 14 days and maintained at 21 days (D). **P <0.01, ***P <0.001 vs. sham-ipsi. One-way ANOVA followed by Newman-Keuls test. n = 6 mice per group.

Back to article page