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Figure 3 | Journal of Neuroinflammation

Figure 3

From: NFκB-mediated CXCL1 production in spinal cord astrocytes contributes to the maintenance of bone cancer pain in mice

Figure 3

Intrathecal injection of CXCL1 neutralizing antibody attenuates bone cancer pain. CXCL1 neutralizing antibody at a lower dose (4 μg) had mild effect on RM-1 cell inoculation-induced pain hypersensitivity (A, B), whereas the neutralizing antibody at a higher dose (8 μg) reversed inoculation-induced mechanical allodynia (A) and heat hyperalgesia (B) for more than 6 h. *P <0.05, **P <0.01, ***P <0.001 vs. control serum. n = 6 mice per group.

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Journal of Neuroinflammation

ISSN: 1742-2094