Figure 2
From: Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice
Electrophysiological properties of the commissural-collateral input in the CA1 region of the hippocampus at 1Â week post-traumatic brain injury (TBI). (A) Representative responses in slices from the contralateral (Contra; left) and the TBI (controlled cortical impact (CCI), right) hippocampus before and after the tetanus. (B) Long-term potentiation (LTP) of monosynaptic responses after CCI. (C) Changes of polysynaptic response (averaged amplitude at latencies 12 to 45Â ms after the stimulus). (D) Enhanced NADPH oxidase (Nox) activity in both ipsilateral and contralateral hemispheres 24Â hours and 1Â week post-TBI as shown by increased superoxide electron paramagnetic resonance (EPR) signal amplitude relative to sham animals. (E) Isolated synaptosomes from the ipsilateral side exhibited greater Nox activity, which increased 1Â week post-CCI. Con, control; Contra, contralateral; fEPSP, field excitatory postsynaptic potential; Ispi, ipsilateral.