Table 2 ROC curve of GABA (μmol/L), serotonin (ng/mL), dopamine (ng/L), oxytocin (μLU/mL), and IFI16 (ng/mL) in autistic groups
From: Association of social and cognitive impairment and biomarkers in autism spectrum disorders
| Â | Â | Patients with autism | CARS | SRS | ||
|---|---|---|---|---|---|---|
Parameters | Mild to moderate | Severe | Mild to moderate | Severe | ||
GABA (μmol/L) | Area under the curve | 0.883 | 0.843 | 1.000 | 0.864 | 0.993 |
| Â | Best cutoff value | 0.170 | 0.170 | 0.257 | 0.170 | 0.257 |
| Â | Sensitivity% | 90.0% | 85.7% | 100.0% | 91.7% | 93.3% |
| Â | Specificity% | 80.0% | 80.0% | 100.0% | 80.0% | 100.0% |
Serotonin (ng/mL) | Area under the curve | 1.000 | 1.000 | 0.997 | 1.000 | 1.000 |
| Â | Best cutoff value | 59.925 | 55.225 | 56.400 | 51.700 | 56.400 |
| Â | Sensitivity% | 100.0% | 100.0% | 96.0% | 100.0% | 100.0% |
| Â | Specificity% | 100.0% | 100.0% | 100.0% | 100.0% | 100.0% |
Dopamine (ng/L) | Area under the curve | 0.968 | 0.993 | 0.959 | 1.000 | 0.969 |
| Â | Best cutoff value | 477.771 | 463.014 | 490.207 | 433.682 | 490.207 |
| Â | Sensitivity% | 92.9% | 100.0% | 94.1% | 100.0% | 100.0% |
| Â | Specificity% | 88.9% | 92.6% | 85.2% | 100.0% | 85.2% |
Oxytocin (μLU/mL) | Area under the curve | 0.981 | 0.973 | 0.990 | 0.979 | 0.989 |
| Â | Best cutoff value | 92.105 | 92.105 | 85.555 | 92.105 | 109.720 |
| Â | Sensitivity% | 90.0% | 85.2% | 95.7% | 90.0% | 100.0% |
| Â | Specificity% | 100.0% | 100.0% | 100.0% | 100.0% | 90.0% |
IFI16 (ng/mL) | Area under the curve | 0.933 | 0.916 | 0.973 | 0.918 | 0.978 |
| Â | Best cutoff value | 1.750 | 1.750 | 2.320 | 1.860 | 2.330 |
| Â | Sensitivity% | 100.0% | 100.0% | 92.0% | 90.5% | 95.2% |
| Â | Specificity% | 70.0% | 70.0% | 90.0% | 80.0% | 90.0% |