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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

Figure 2

Astrogliotic changes in the anterior horns of spinal cords from mSOD1-Tg mice. (A) GFAP immunostaining reveals normal-shaped astrocytic cytoplasm and fine processes in the anterior horns of spinal cords from non-Tg mice, whereas (B) numerous gemistocytes are visible in the anterior horns of spinal cord from mSOD1-Tg mice at 18 weeks of age. (C,D) Immunoreactivities for Cx43 and AQP4 are increased in the anterior horns of the spinal cords of mSOD1-Tg mice. (E,F) By contrast, expressions of EAAT2 are downregulated in the anterior horns of mSOD1-Tg mice compared with non-Tg mice (arrows). (G,H) At higher magnification, immunoreactivity for EAAT2 is markedly diminished in the anterior horns of mSOD1-Tg mice compared with non-Tg mice. Scale bar; 20 μm (A-D,G,H), 200 μm (E,F).

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Journal of Neuroinflammation

ISSN: 1742-2094