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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

Figure 3

Decreased membranous expressions of Cx47 and Cx32 in mSOD1-Tg mice at 20 weeks of age. (A-C) Immunoreactivity for Cx47 is normally present at the surface membrane of oligodendrocytes in non-Tg mice at 20 weeks of age, while (D-F) membranous staining of Cx47 is markedly decreased and internalized to the cytoplasm of oligodendrocytes in the anterior horns of mSOD1-Tg mice at the same age (arrows). (G-I) Immunoreactivity for Cx32 is also mainly localized at the membrane of oligodendrocyte somata in non-Tg mice (arrows), whereas (J-L) Cx32 expression in oligodendrocyte somata is diminished in the anterior horns of mSOD1-Tg mice at 20 weeks of age (arrows). (H,I) Asterisks show motor neurons adjacent to oligodendrocytes. (E,K) Oligodendrocytes in the anterior horns of mSOD1-Tg mice demonstrate an abnormal-shaped morphology. The nucleus is stained with DAPI (A-L, blue). Scale bar; 10 μm (A-L).

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