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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

Figure 5

Quantitative immunoblot analysis of Cxs in mSOD1-Tg and non-Tg mice at 20 weeks of age. (A) Representative images of GFAP, EAAT2, Cx43, Cx30, Cx32, Cx47, and MOG immunoblots obtained from mSOD1-Tg mice and non-Tg mice (n = 5 per group) at 20 weeks of age. GAPDH blots for loading controls are shown under each protein blot. (B) Results of quantitative analysis for each astrocyte or oligodendrocyte marker. The expression levels of Cx47, Cx32, and EAAT2 are significantly decreased in mSOD1-Tg mice than in non-Tg mice. By contrast, the expression levels of GFAP are significantly increased in mSOD1-Tg mice as compared with non-Tg mice. Cx43, Cx30, and MOG expressions are not significantly different between mSOD1-Tg and non-Tg mice.

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