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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model

Figure 7

Overexpression of SOD1 in oligodendrocytes of mSOD1-Tg mice. (A-C) Immunoreactivity for SOD1 is observed in the nuclei and cytoplasm of oligodendrocytes in the anterior horns of non-Tg mice at 20 weeks of age and immunoreactivity for Cx47 is preserved at the surface of oligodendrocytes. (D-F) However, SOD1 is markedly accumulated in neurons and astrocytes in the anterior horns of mSOD1-Tg mice at 20 weeks of age and accumulation of SOD1 was also observed in oligodendrocytes with Cx47-immunopositivity in their cytoplasm (arrows). Membranous staining of Cx47 is not visible in abnormal-shaped oligodendrocytes. The nucleus is stained with DAPI (A-F blue). Scale bar; 5 μm (A-F).

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Journal of Neuroinflammation

ISSN: 1742-2094