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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation

Figure 1

Cellular distribution of Na v 1.8 in rat DRG neurons. (A–F) Immunohistochemical distribution of Nav1.8 in DRG neurons isolated from sham and CFA-treated rats. Panels show the localization of Nav1.8 (green) in NF200-positive neurons (red, arrowheads). Yellow signal indicates double-labeled neurons. After inflammation, numerous large NF200-positive ganglion cells co-express Nav1.8 (arrows). (G) Proportion of Nav1.8-immunoreactive neurons in lumbar DRGs. The number of neurons expressing Nav1.8 increases in CFA-inflamed rats compared to sham. (H) Percentage of NF200-containing DRG neurons expressing Nav1.8. The proportion of dually stained cells increases after CFA-induced chronic inflammation. Data in panels G and H shown as mean ± SEM. Asterisks denote a statistically significant increase as compared with sham (4 rats/group, 10 sections/rat; ***P <0.001 or **P <0.01; ANOVA followed by Sidak’s multiple comparisons test MCT)). #Statistically different from day 3; ### P <0.001, ## P <0.01, # P <0.05). Scale bars: 200 μm in A, C, and E and 20 μm in B, D, and F.

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