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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Functional up-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheral inflammation

Figure 2

Changes in the expression and distribution of Na v 1.8 associated with CFA-induced inflammation in rats. (A) Nav1.8 mRNA levels of the ipsilateral hind paw are determined by qRT-PCR for sham animals and 14 days following CFA injection. Data are expressed as mean ± SEM (6–8 rats/group). **P <0.01, CFA alone vs. sham (unpaired Student’s t-test). (B, C) Immunohistochemical staining of Nav1.8 channels in the rat sciatic nerve proximal to the lesion site 48 h after ligation. The ligature was placed around the sciatic nerve proximal to the trifurcation on day 12 post-CFA. Scale bar: 100 μm. (D) Accumulation of Nav1.8-like immunoreactivity is significantly increased in 14 day post-CFA rats compared to sham animals (*P <0.05; unpaired Student’s t-test).

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