Figure 7
Effect of ambroxol on CFA-induced mechanical allodynia and edema. Mechanical sensitivity (A) and volume (B) of the ipsilateral hind paw are determined for sham animals and 14 days following CFA injection. Effects of ambroxol (0.3 mg/kg cumulative dose) were determined 1 h following administration of the last of 3 intrathecal injections (0.1 mg/kg injected on days 3, 8, and 14) on day 14 post-CFA. Data are expressed as mean ± SEM (6–8 rats/group). ***P <0.001, compared to sham. ## P <0.01, ### P <0.001 vs. CFA ipsilateral alone; One-way ANOVA followed by Sidak’s post-hoc comparisons test.