Paroxetine relieves microglia-mediated neurotoxicity. BV2 cells were first treated with lipopolysaccharide (LPS) (100 ng/mL) for 24 hours with or without 30 minutes of paroxetine pretreatment at 5 μM. The media were then collected as condition media and added to SH-SY5Y cells. After 24 hours incubation, cell viability of SH-SY5Y was assessed and expressed as percentage of the control, which was set as 100%. *P < 0.05. Values are means ± SE of three independent experiments. PAR, paroxetine; LPS, lipopolysaccharide.