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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Figure 2

Cooperation among microglia receptors in Aβ recognition, uptake and signaling. (a) Aβ fibrils are recognized by the complex CD36-α6β1-CD47, generating ROS production. The interaction between CD36 and Aβ provides signals for the assembly of the heterodimer TLR4-TLR6 complex. (b) CD36-TLR4-TLR6 complex activation constitutes the first signal for the transcription of Nlrp3 and il1b. (c) CD36 mediates the internalization of Aβ into the lysosomal compartment. Lysosomal disruption constitutes the second signal for the NLRP3 assembly and the subsequent cleavage of pro-IL-1β, rendering the mature IL-1β. (d) The activation of TLR4 also induces the overexpression of SR-AI, which contributes to the clearance of Aβ.

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