Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Table 1 Summary of microglia receptors and their effects in AD pathogenesis

Receptors	Expression in brain cells	Role in AD pathogenesis	References
Complement receptors	Neurons, microglia, astrocytes and oligodendrocytes	Microglia activation, cytokine expression and Aβ clearance	[25, 26, 28, 30, 31, 33, 34, 37]
Fc receptors	Neurons, microglia, astrocytes and oligodendrocytes	Inflammatory response and Aβ clearance	[41, 45]
FPRL1/FPR2	Microglia, astrocytes	Microglia activation, inflammatory response and Aβ internalization	[61, 65, 66, 68, 71, 167]
SR-A	Microglia, astrocytes	Aβ internalization and clearance	[85, 88]
CD36	Neurons, microglia, astrocytes	Microglia recruitment, activation and Aβ phagocytosis	[77, 102, 106, 155]
RAGE	Neurons, microglia and astrocytes	Microglia activation and cytokine expression	[113, 115–118]
TLR	Microglia, astrocytes	Microglia activation, inflammatory response and Aβ clearance	[131, 132, 139, 143–145, 148]
NLRP3	Microglia	Cytokine expression	[149, 153]
CD33	Microglia	Impairs microglia Aβ clearance	[159, 160]
TREM2	Microglia, neurons	Aβ clearance	[162–166]

Aβ, amyloid β; AD, Alzheimer’s disease; FPR, formyl peptide receptors; NLRP, nod-like-receptor protein; RAGE, receptor for advanced glycosylation endproducts; SR-A, scavenger receptor A; TLR, toll-like receptor; Trem2, triggering receptor expressed by myeloid cells 2.

ISSN: 1742-2094