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Table 1 The mRNA levels of opioid genes and macrophage/microglia markers in two brain regions in HIV- and HIV+ subjects

From: Neurocognitive and neuroinflammatory correlates of PDYN and OPRK1 mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects

 

Caudate

Anterior cingulate

Gene

HIV-

HIV+

   

HIV-

HIV+

   
 

Mean ± SEM

Mean ± SEM

t

df

P value

Mean ± SEM

Mean ± SEM

t

df

P value

OPRK1

8.59 ± 025

8.45 ± 0.14

<1.0

33

N.S.

7.17 ± 0.24

8.32 ± 0.25

3.28

23

<0.005 a

PDYN

2.51b ± 0.27

2.07b ± 0.15

1.45

39

NS

8.05 ± 0.29

7.19 ± 0.13

3.06

37

<0.005

OPRM1

7.16 ± 0.16

7.07 ± 0.16

<1.0

35

N.S.

8.33 ± 0.18

8.44 ± 0.18

<1.0

23

N.S.

CD68

6.34 ± 0.14

6.99 ± 0.12

3.31

34

<0.005

6.65 ± 0.24

7.56 ± 0.12

3.65

23

<0.002

CD163

6.85 ± 0.23

8.05 ± 0.21

3.71

34

<0.001

6.14 ± 0.34

7.37 ± 0.28

2.79

22

<0.02

  1. aGenes with significant expression differences between HIV- and HIV+ individuals are shown in bold. bPDYN mRNA levels in the caudate were measured using RNase protection assay as pg PDYN mRNA/ microgram total RNA.
  2. NS, no significant difference between HIV- and HIV+. Levels of mRNA were determined using RT-PCR, and expressed as natural logarithm of cDNA copy number normalized to copies of GAPDH cDNA copy number.
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Journal of Neuroinflammation

ISSN: 1742-2094