Figure 3

HIV-1 viral protein R (Vpr) expression in the hippocampus causes memory impairment. (A) Exploration time show a significant difference in learning for the control group (green fluorescent protein, GFP) and significant learning impairment for the experimental group (Vpr). Exploration time of the replacement with a novel object, show significant learning for the control group (GFP) and the familiar object show impaired learning for the experimental group (Vpr). Significance was assessed by ANOVA. *P <0.05, **P <0.01. (B) Significant difference in object exploration at the novel location (t Test P <0.0011). Control group (GFP) shows preference for the novel location and the novel object.