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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Astrocytic expression of HIV-1 viral protein R in the hippocampus causes chromatolysis, synaptic loss and memory impairment

Figure 4

Astrocytic HIV-1 viral protein R (Vpr) production induces neuronal chromatolysis. (A) Representative 40× images of the Nissl stained hippocampal sections show reduced staining in Vpr-treated tissues. Chromatolysis was detected by prominent migration of the nucleus toward the periphery of the cell (shown in zoom to right). (B) Normal and chromatolytic neurons were counted from three sections per rat in CA1 and CA3 of both hippocampal hemispheres of green fluorescent protein (GFP)- and Vpr-treated rats. Mean and standard deviation are graphed. Significance was assessed by ANOVA. *P <0.05, **P <0.01. Five rats were counted in each group.

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