IVIg injection modulates the relative populations of T lymphocytes. Flow cytometry analysis of blood cells labeled for leukocytes (CD45), lymphocytes (B220 for B cells and CD3 for T cells), helper (CD4) and cytotoxic (CD8) T cells, and granulocytes (Gr-1). Mice were exposed to IVIg for 3 months and sacrificed at the age of (A) 12 months and (B) 16 months. Results are presented as the mean ± SEM (n = 8 NonTg and n = 11 to 13 3xTg-AD animals per group). Statistical analysis: one-way ANOVA followed by Tukey’s multiple comparison test. *P <0.05, **P <0.01, ***P <0.001 versus NonTg group; ##
P <0.01 versus control 3xTg-AD. 3xTg-AD, triple-transgenic mouse model of Alzheimer’s disease; ANOVA, analysis of variance; ctrl, control; IVIg, human intravenous immunoglobulin; NonTg, non-transgenic.