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Table 2 Levels of proteins in the parietotemporal cortex of 3xTg-AD mice

From: IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology

Biological function Proteins Age group Fraction NonTg ctrl 3xTg-AD ctrl 3xTg-AD IVIg ANOVA Pvalue
Synaptic Snap25 12 months Membrane 1.58 ± 0.38 1.48 ± 0.4 1.46 ± 0.38 0.78
  PSD95 12 months Membrane 1.31 ± 0.33 1.39 ± 0.31 1.39 ± 0.33 0.85
  Septin3 16 months Cytosolic 1.16 ± 0.17 1.55 ± 0.38* 1.60 ± 0.42* 0.04
  Dynamin1 16 months Membrane 1.56 ± 0.23 1.38 ± 0.15 1.50 ± 0.12 0.75
  Drebrin 16 months Membrane 1.35 ± 0.24 1.57 ± 0.55 1.63 ± 0.41 0.36
  Synaptophysin 16 months Membrane 6.73 ± 1.5 6.86 ± 1.13 6.82 ± 1.16 0.97
Others VILIP-1 12 months Cytosolic 3.01 ± 0.59 2.68 ± 0.42 2.58 ± 0.35 0.10
  VILIP-1 16 months Cytosolic 1.74 ± 0.19 1.58 ± 0.31 1.58 ± 0.25* 0.01
  ADAM-10 12 months Cytosolic 8.08 ± 0.45 7.38 ± 0.23 7.55 ± 0.39 0.43
  ADAM-10 16 months Cytosolic 7.97 ± 0.51 8.27 ± 0.37 7.36 ± 0.24 0.27
  PAK 16 months Cytosolic 8.05 ± 2.49 6.81 ± 0.71 7.50 ± 0.93 0.07
  1. Western blot analyses. Equal loading of samples was determined by protein quantification and actin staining. Values are expressed as the mean ± SEM of RLU (n = 7 to 13 animals). Statistical analysis: one-way ANOVA followed with Tukey’s multiple comparison test. *P <0.05 versus NonTg ctrl; § P <0.05 versus 3xTg-AD ctrl. 3xTg-AD, triple-transgenic mouse model of Alzheimer’s disease; ADAM-10, a disintegrin and metalloproteinase domain containing protein 10; ANOVA, analysis of variance; ctrl, control; IVIg, human intravenous immunoglobulin; NonTg, non-transgenic; PAK, p21-activated kinase; PSD95, postsynaptic density protein 95; RLU, relative luminescence unit; Snap25, synaptosomal-associated protein 25; VILIP-1, visinin-like protein-1.