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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

Figure 1

Anti-ionized calcium binding adaptor molecule 1 (Iba1) and tomato lectin labeling in amyotrophic lateral sclerosis-linked mutant human superoxide dismutase transgene (SOD1 G93A ) and wild-type (WT) lumbar spinal cord ventral horn. Few Iba1-positive microglia (arrows in A-D) were present in the ventral horn at 6 weeks of age in WT (A) and SOD1G93A (B) mice. The number of microglia was not increased at 25 weeks of age in WT mice (C), but was substantially increased at 25 weeks (disease endpoint, EP) in SOD1G93A mice (D). Microglial labeling with Iba1 (E) and tomato lectin (F) increased with disease progression. Scale bar 50 μm in A-D. * P < 0.05, ** P < 0.01, *** P < 0.001. NY, Nuclear yellow.

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Journal of Neuroinflammation

ISSN: 1742-2094