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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

Figure 2

Arginase1 (Arg1) expression in microglia of amyotrophic lateral sclerosis-linked mutant human superoxide dismutase transgene (SOD1 G93A ) and wild-type (WT) lumbar spinal cord ventral horn. A subset of ventral horn tomato lectin (TL)-positive (red) microglia expressed Arg1 (green) (arrows, A-D) at 10 weeks of age in both WT (A) and SOD1G93A (B) mice. The number of microglia expressing Arg1 was unchanged at 22 weeks of age in WT mice (C); in contrast, 22-week SOD1G93A spinal cord (D) showed a far greater number of Arg1-positive microglia. The numbers of Arg1-negative and Arg1-positive microglia remained constant over time in WT mice (E). The number of Arg1-positive microglia increased with disease progression in SOD1G93A mice (F). Scale bar 50 μm in A-D. * P < 0.05, ** P < 0.01, *** P < 0.001. NY, Nuclear yellow; EP, endpoint

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Journal of Neuroinflammation

ISSN: 1742-2094