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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

Figure 4

Percentage area occupied by arginase1 (Arg1) and inducible nitric oxide synthase (iNOS) immunoreactivity in amyotrophic lateral sclerosis-linked mutant human superoxide dismutase transgene (SOD1 G93A ) lumbar spinal cord microglia. The percentage area of the microglial cell body occupied by Arg1 (A,B) or iNOS (C,D)  positive immunoreactivity was examined at 6 weeks (A,C) and 22 weeks (B,D) of age in a subset of microglia displaying the strongest immunoreactivity. The percentage of cell body area occupied by Arg1 was higher at 22 weeks of age than at 6 weeks of age; the percentage of cell body area occupied by iNOS was also higher at 22 weeks of age than at 6 weeks of age (E). Scale bar 10 μm in A-D. *** P < 0.01. TL, tomato lectin; NY, Nuclear yellow.

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Journal of Neuroinflammation

ISSN: 1742-2094