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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase

Figure 5

Expression of arginase1 (Arg1) and inducible nitric oxide synthase (iNOS) in microglia of the ventral horn of wild-type (WT) and amyotrophic lateral sclerosis-linked mutant human superoxide dismutase transgene (SOD1 G93A ) cervical spinal cord. The number of Arg1-negative and Arg1-positive cervical microglia remained relatively constant over time in WT mice (A). In the cervical spinal cord of SOD1G93A mice, the number of Arg1-positive and Arg1-negative microglia remained equivalent until 22 weeks of age, when there was an increase in the number of Arg1-positive microglia (B). There were greater numbers of iNOS-negative microglia than iNOS-positive microglia throughout the time course in WT mice (C). The numbers of iNOS-positive microglia and iNOS-negative microglia both increased with disease progression in the SOD1G93A cervical spinal cord (D). * P < 0.05, ** P < 0.01, *** P < 0.001.

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