Figure 8

Functional measures of disease progression in wild-type (WT) and amyotrophic lateral sclerosis-linked mutant human superoxide dismutase transgene (SOD1 ^G93A ) mice. Body weight increased continuously in WT mice but followed a curved trajectory in SOD1^G93A mice, becoming significantly less than that of WT mice at 14 weeks of age and reaching peak body weight at approximately 16 weeks of age (A). WT mice were able to maintain wire hang duration throughout the study, while SOD1^G93A mice became unable to maintain a 60-second hang duration from 15 weeks of age onwards (B). SOD1^G93A mice displayed a lower stride length (C) and a higher uniformity measure (D) than WT mice at 18 weeks and thereafter. Front-base width (E) and hind-base width (F) showed no consistent changes between WT and SOD1^G93A mice over time. * P < 0.05, P < 0.01, ^# P < 0.001.