Figure 2

Aspirin-induced neuroprotection. Rats received various aspirin treatments around a 90-minute middle cerebral arterial occlusion (MCAO). The results were evaluated at 3 days after the MCAO. (A) Brain slices stained with 2,3,5-triphenyltetrazolium chloride from representative mice. (B) Percentage of brain infarct volume in ipsilateral hemisphere volume. (C) Neurological deficit scores evaluated immediately before the animals were euthanized for the assessment of infarct sizes (data are presented in panel B). ●, Lowest or highest score (the score will not show up if it falls in the 95% interval); between lines, 95% interval of the data; inside boxes, 25-75% interval including the median of the data. (D) The performance on rotarod. Rats were tested before and 3 days after the MCAO and the speed–latency index ratio of these two tests are presented. All results except for those in panel C are the means ± SEM (n = 10). *P < 0.05, compared with the animals subjected to MCAO only. ASA, acetylsalicylic acid.