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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat

Figure 3

Aspirin-induced inhibition of Notch activation and proinflammatory cytokine production. Rats received various aspirin treatments around a 90-minute middle cerebral arterial occlusion (MCAO). The right frontal cortex area 1 was harvested at 24 hours after the MCAO. The cytosol was prepared for Western blotting for Notch intracellular domain (NICD) and ELISA for IL-6 and IL-1β. (A) NICD expression. Top panel shows representative Western blots and bottom panel shows the quantification results. (B) IL-6 results. (C) IL-1β results. Results are the means ± SEM (n = 8). *P < 0.05, compared with sham operated animals; ^P < 0.05, compared with the animals subjected to MCAO only. ASA, acetylsalicylic acid.

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