Involvement of peroxisome proliferator-activated receptors on the protective actions of DHA following spinal cord trauma. Following spinal cord compression, significant damage to the spinal cord from PPARα KO mice (B) at the perilesional zone was observed by H & E staining when compared with spinal cord tissue collected from the sham group (A). The genetic absence of the PPAR-α receptor significantly blocked the effect of the DHA treatment (C). The histological score (D) was made by an independent observer. These figures are representative of at least three experiments performed on different experimental days. Data are mean ± SEM of ten mice for each group. *P < 0.01 vs sham; °P < 0.01 vs SCI.