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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Enhanced uptake of multiple sclerosis-derived myelin by THP-1 macrophages and primary human microglia

Figure 3

Increased uptake of MS myelin by primary human microglia after 24 hours. (A) Flow-cytometric analysis of live cells defined by forward and sideward scatter (FSC and SSC) characteristics and the viability dye eFluor were analyzed for uptake of pHrodo-labeled myelin after 24 hours of incubation. (B) Histograms showing uptake of 11 MS and 12 control myelin samples (pHrodo signal) after 24 hours. (C) Microglia phagocytosed MS myelin more efficiently than control myelin after 24 hours. The amount of myelin phagocytosed (geoMFI) was significantly higher when cells were incubated with MS myelin. Shown is the mean of 10 independent experiments. Data were analyzed with the Mann Whitney U test. HC, healthy control; MS, multiple sclerosis.

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Journal of Neuroinflammation

ISSN: 1742-2094