Enhanced uptake of multiple sclerosis-derived myelin by THP-1 macrophages and primary human microglia

Table 3 Comparison of phagocytosis of MS versus control myelin in the different matched subgroups

	Myelin uptake	All donors	Matched for age	Matched for PMD
THP-1 (6 hours)	Percentage	0.0010^b	0.012^a	0.0023^b
THP-1 (6 hours)	GeoMFI	0.0005^c	0.0016^b	0.0082^a
THP-1 (24 hours)	Percentage	0.0006^b	0.0004^c	0.0082^a
THP-1 (24 hours)	GeoMFI	0.0001^c	0.0008^b	0.0023^b
Microglia (24 hours)	Percentage	0.4791	0.3884	0.9452
Microglia (24 hours)	GeoMFI	0.0106^a	0.0496^a	0.0734

GeoMFI, geomean fluorescence intensity; PMD, postmortem delay. ^a P < 0.05; ^b P < 0.005; ^c P < 0.0005.
Comparison in uptake of MS versus control myelin by THP-1 macrophages after 6 and 24 hours, and by primary human microglia after 24 hours, expressed as the percentage of cells that had phagocytosed myelin and as the amount of myelin taken up by the cells (geoMFI). Data were analyzed with the Mann–Whitney U test. P values are provided for of all myelin samples, as well as for age- and PMD-matched subgroups.

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