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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons

Figure 2

Intrathecal injection of CCL2 strengthens glutamatergic transmission in lamina II neurons via a presynaptic mechanism. (A) One day after intrathecally injecting vehicle or CCL2 (1 μg) into the rats, spontaneous mEPSCs were recorded from outer lamina II neurons in spinal cord slices. Compared to a control lamina II neuron, the frequency of spontaneous mEPSCs was significantly increased in a lamina II neuron from a CCL2-injected rat. V H = -60 mV. (B) Intrathecal administration of CCL2 (1 μg) greatly increased the frequency of mEPSCs in substantia gelatinosa neurons without affecting the mean amplitude. Each bar shows mean ± standard error for 12 neurons from 6 rats. *P < 0.01 compared to control neurons. Con, control; mEPSC, miniature excitatory postsynaptic current.

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Journal of Neuroinflammation

ISSN: 1742-2094