PD168393 improved functional outcome and bladder recovery after spinal cord injury (SCI). The Basso, Bresnahan, and Beattie (BBB) scores of hindlimb locomotion were assessed at day 1 post-injury and weekly thereafter. Repeated-measures ANOVA revealed significant difference between injury and PD168393-treated animals (P < 0.01) (A). The PD168393-treated rats had less residual urine compared with non-treated injured rats. Statistical analysis between animal groups showed significant differences (P < 0.05) (B) (n = 5/group).