Table 2 Significance of differentially expressed target genes following acute inflammatory models
From: Peripheral inflammation is associated with remote global gene expression changes in the brain
Gene | Significance of fold change in treatment group compared to vehicle control group (↑, upregulated; ↓, downregulated) | |||||
|---|---|---|---|---|---|---|
|  | LPS (P) | TNFα (P) | LTA (P) | |||
| Â | Brain | PBLs | Brain | PBLs | Brain | PBLs |
Ctsc | ↑ 0.0332 | ↑ 0.0283 | Not significant | Not significant | Not significant | Not significant |
Cxcl10 | ↑ 0.0122 | ↑ 0.0329 | Not significant | ↓ 0.0016 | Not significant | Not significant |
Gbp2 | ↑ 0.0160 | Not significant | Not significant | ↓ 0.0288 | Not significant | Not significant |
Gbp3 | ↑ 0.0197 | Not significant | Not significant | ↓ 0.0179 | Not significant | Not significant |
Gbp4 | ↑ 0.0030 | Not significant | ↑ 0.0334 | ↓ 0.0478 | Not significant | Not significant |
Ifit1 | ↑ 0.0027 | ↑ 0.0010 | Not significant | Not significant | Not significant | Not significant |
Ifitm3 | ↑ 0.0016 | ↑ 0.0001 | Not significant | Not significant | Not significant | ↑ 0.0481 |
Igrm1 | ↑ 0.0343 | ↑ 0.0311 | Not significant | Not significant | Not significant | Not significant |
Irf7 | ↑ 0.0004 | Not significant | Not significant | Not significant | Not significant | Not significant |
Lgals3bp | ↑ 0.0012 | ↑ 0.0055 | Not significant | Not significant | Not significant | ↑ 0.0030 |
Oasl2 | ↑ 0.0075 | ↑ 0.0008 | Not significant | Not significant | Not significant | Not significant |
Rtp4 | ↑ 0.0044 | ↑ 0.0010 | Not significant | Not significant | Not significant | Not significant |
Sp100 | Not significant | ↓ 0.0101 | Not significant | ↓ 0.0062 | Not significant | Not significant |
Stat1 | Not significant | Not significant | ↑ 0.0252 | ↓ 0.0371 | Not significant | Not significant |