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Table 2 Significance of differentially expressed target genes following acute inflammatory models

From: Peripheral inflammation is associated with remote global gene expression changes in the brain

Gene Significance of fold change in treatment group compared to vehicle control group (↑, upregulated; ↓, downregulated)
  LPS (P) TNFα (P) LTA (P)
  Brain PBLs Brain PBLs Brain PBLs
Ctsc ↑ 0.0332 ↑ 0.0283 Not significant Not significant Not significant Not significant
Cxcl10 ↑ 0.0122 ↑ 0.0329 Not significant ↓ 0.0016 Not significant Not significant
Gbp2 ↑ 0.0160 Not significant Not significant ↓ 0.0288 Not significant Not significant
Gbp3 ↑ 0.0197 Not significant Not significant ↓ 0.0179 Not significant Not significant
Gbp4 ↑ 0.0030 Not significant ↑ 0.0334 ↓ 0.0478 Not significant Not significant
Ifit1 ↑ 0.0027 ↑ 0.0010 Not significant Not significant Not significant Not significant
Ifitm3 ↑ 0.0016 ↑ 0.0001 Not significant Not significant Not significant ↑ 0.0481
Igrm1 ↑ 0.0343 ↑ 0.0311 Not significant Not significant Not significant Not significant
Irf7 ↑ 0.0004 Not significant Not significant Not significant Not significant Not significant
Lgals3bp ↑ 0.0012 ↑ 0.0055 Not significant Not significant Not significant ↑ 0.0030
Oasl2 ↑ 0.0075 ↑ 0.0008 Not significant Not significant Not significant Not significant
Rtp4 ↑ 0.0044 ↑ 0.0010 Not significant Not significant Not significant Not significant
Sp100 Not significant ↓ 0.0101 Not significant ↓ 0.0062 Not significant Not significant
Stat1 Not significant Not significant ↑ 0.0252 ↓ 0.0371 Not significant Not significant
  1. Significance of differential gene expression was calculated separately for individual genes in each tissue using an unpaired t test.