Figure 2
From: Critical role of TNF-α in cerebral aneurysm formation and progression to rupture
The role of TNF-α in the formation of intracranial aneurysms. (A) Cerebral aneurysm formation was significantly increased in mice receiving vehicle as compared to TNF-α knockout mice and those pre-treated with DTH. (B) The incidence of aneurysm rupture was also significantly increased in mice receiving vehicle versus TNF-α knockout mice and those pre-treated with DTH. (C) Kaplan-Meier analysis demonstrates that aneurysm rupture occurred between 7 and 21 days following aneurysm induction, and mice receiving vehicle were more likely to have ruptured aneurysms as compared to TNF-α knockout mice and those pre-treated with DTH. DTH, 3,6'dithiothalidomide.