Figure 4From: Critical role of TNF-α in cerebral aneurysm formation and progression to rupture TNF-α mRNA expression. As compared with sham mice receiving vehicle, real-time PCR demonstrated no significant difference in TNF-α mRNA expression of cerebral blood vessels from TNF-α knockout mice or those pre-treated with DTH, but TNF-α was significantly elevated in unruptured and furthermore in ruptured aneurysms. DTH, 3,6'dithiothalidomide.Back to article page