Aneurysm stabilization with DTH. (A) There was no significant difference in the overall incidence of aneurysm formation between cohorts treated with DTH and those treated with vehicle. (B) The incidence of rupture was significantly decreased in those treated with DTH as compared to vehicle. (C) The rate of cerebral aneurysm rupture in those with cerebral aneurysm formation was significantly decreased in those treated with DTH as compared with vehicle. (D) After eliminating those animals without aneurysm formation, Kaplan-Meier analysis demonstrated that those receiving delayed DTH treatment were 5.8 times (95% CI 1.3 to 25.5, P = 0.020) less likely to have aneurysmal rupture than those receiving vehicle. DTH, 3,6'dithiothalidomide.