TY - JOUR AU - Akira, S. AU - Takeda, K. PY - 2004 DA - 2004// TI - Toll-like receptor signalling JO - Nat Rev Immunol VL - 4 UR - https://doi.org/10.1038/nri1391 DO - 10.1038/nri1391 ID - Akira2004 ER - TY - JOUR AU - Finsen, B. AU - Owens, T. PY - 2011 DA - 2011// TI - Innate immune responses in central nervous system inflammation JO - FEBS Lett VL - 585 UR - https://doi.org/10.1016/j.febslet.2011.05.030 DO - 10.1016/j.febslet.2011.05.030 ID - Finsen2011 ER - TY - JOUR AU - Hanisch, U. K. AU - Johnson, T. V. AU - Kipnis, J. PY - 2008 DA - 2008// TI - Toll-like receptors: roles in neuroprotection? JO - Trends Neurosci VL - 31 UR - https://doi.org/10.1016/j.tins.2008.01.005 DO - 10.1016/j.tins.2008.01.005 ID - Hanisch2008 ER - TY - JOUR AU - Medzhitov, R. PY - 2011 DA - 2011// TI - Toll-like receptors and innate immunity JO - Nat Rev Immunol VL - 1 UR - https://doi.org/10.1038/35100529 DO - 10.1038/35100529 ID - Medzhitov2011 ER - TY - JOUR AU - Lucas, K. AU - Maes, M. PY - 2013 DA - 2013// TI - Role of the toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway JO - Mol Neurobiol VL - 48 UR - https://doi.org/10.1007/s12035-013-8425-7 DO - 10.1007/s12035-013-8425-7 ID - Lucas2013 ER - TY - JOUR AU - Akira, S. AU - Uematsu, S. AU - Takeuchi, O. PY - 2006 DA - 2006// TI - Pathogen recognition and innate immunity JO - Cell VL - 124 UR - https://doi.org/10.1016/j.cell.2006.02.015 DO - 10.1016/j.cell.2006.02.015 ID - Akira2006 ER - TY - JOUR AU - Hanke, M. L. AU - Kielian, T. PY - 2011 DA - 2011// TI - Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential JO - Clin Sci (Lond) VL - 121 UR - https://doi.org/10.1042/CS20110164 DO - 10.1042/CS20110164 ID - Hanke2011 ER - TY - STD TI - Piccinini AM, Midwood KS: DAMPening inflammation by modulating TLR signalling. Mediators Inflamm. Epub 2010 Jul 13. Mediators Inflamm. 2010;2010. doi: 10.1155/2010/672395. Epub 2010 Jul 13 ID - ref8 ER - TY - JOUR AU - Fischer, M. AU - Ehlers, M. PY - 2008 DA - 2008// TI - Toll-like receptors in autoimmunity JO - Ann N Y Acad Sci VL - 1143 UR - https://doi.org/10.1196/annals.1443.012 DO - 10.1196/annals.1443.012 ID - Fischer2008 ER - TY - JOUR AU - Kigerl, K. A. AU - Popovich, P. G. PY - 2009 DA - 2009// TI - Toll-like receptors in spinal cord injury JO - Curr Top Microbiol Immunol VL - 336 ID - Kigerl2009 ER - TY - JOUR AU - Takeuchi, O. AU - Akira, S. PY - 2001 DA - 2001// TI - Toll-like receptors; their physiological role and signal transduction system JO - Int Immunopharmacol VL - 1 UR - https://doi.org/10.1016/S1567-5769(01)00010-8 DO - 10.1016/S1567-5769(01)00010-8 ID - Takeuchi2001 ER - TY - JOUR AU - Shimazu, R. AU - Akashi, S. AU - Ogata, H. AU - Nagai, Y. AU - Fukudome, K. AU - Miyake, K. AU - Kimoto, M. PY - 1999 DA - 1999// TI - MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4 JO - J Exp Med VL - 189 UR - https://doi.org/10.1084/jem.189.11.1777 DO - 10.1084/jem.189.11.1777 ID - Shimazu1999 ER - TY - JOUR AU - Means, T. K. AU - Golenbock, D. T. AU - Fenton, M. J. PY - 2000 DA - 2000// TI - The biology of toll-like receptors JO - Cytokine Growth Factor Rev VL - 11 UR - https://doi.org/10.1016/S1359-6101(00)00006-X DO - 10.1016/S1359-6101(00)00006-X ID - Means2000 ER - TY - JOUR AU - Madrigal, J. L. AU - García-Bueno, B. AU - Caso, J. R. AU - Pérez-Nievas, B. G. AU - Leza, J. C. PY - 2006 DA - 2006// TI - Stress-induced oxidative changes in brain JO - CNS Neurol Disord Drug Targets VL - 5 UR - https://doi.org/10.2174/187152706778559327 DO - 10.2174/187152706778559327 ID - Madrigal2006 ER - TY - JOUR AU - Raison, C. L. AU - Capuron, L. AU - Miller, A. H. PY - 2006 DA - 2006// TI - Cytokines sing the blues: inflammation and the pathogenesis of depression JO - Trends Immunol VL - 27 UR - https://doi.org/10.1016/j.it.2005.11.006 DO - 10.1016/j.it.2005.11.006 ID - Raison2006 ER - TY - JOUR AU - Maes, M. AU - Coucke, F. AU - Leunis, J. C. PY - 2007 DA - 2007// TI - Normalization of the increased translocation of endotoxin from gram negative enterobacteria (leaky gut) is accompanied by a remission of chronic fatigue syndrome JO - Neuro Endocrinol Lett VL - 28 ID - Maes2007 ER - TY - JOUR AU - Herbert, T. B. AU - Cohen, S. PY - 1993 DA - 1993// TI - Stress and immunity in humans: a meta-analytic review JO - Psychosom Med VL - 55 UR - https://doi.org/10.1097/00006842-199307000-00004 DO - 10.1097/00006842-199307000-00004 ID - Herbert1993 ER - TY - JOUR AU - García-Bueno, B. AU - Caso, J. R. AU - Leza, J. C. PY - 2008 DA - 2008// TI - Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms JO - Neurosci Biobehav Rev VL - 32 UR - https://doi.org/10.1016/j.neubiorev.2008.04.001 DO - 10.1016/j.neubiorev.2008.04.001 ID - García-Bueno2008 ER - TY - JOUR AU - Buchanan, M. M. AU - Hutchinson, M. AU - Watkins, L. R. AU - Yin, H. PY - 2010 DA - 2010// TI - Toll-like receptor 4 in CNS pathologies JO - J Neurochem VL - 114 ID - Buchanan2010 ER - TY - JOUR AU - Ponferrada, A. AU - Caso, J. R. AU - Alou, L. AU - Colón, A. AU - Sevillano, D. AU - Moro, M. A. AU - Lizasoain, I. AU - Menchén, P. AU - Gómez-Lus, M. L. AU - Lorenzo, P. AU - Cos, E. AU - Leza, J. C. AU - Menchén, L. PY - 2007 DA - 2007// TI - The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction JO - Gastroenterology VL - 132 UR - https://doi.org/10.1053/j.gastro.2007.02.032 DO - 10.1053/j.gastro.2007.02.032 ID - Ponferrada2007 ER - TY - JOUR AU - Maes, M. AU - Kubera, M. AU - Leunis, J. C. PY - 2008 DA - 2008// TI - The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression JO - Neuro Endocrinol Lett VL - 29 ID - Maes2008 ER - TY - JOUR AU - Zacharowski, K. AU - Zacharowski, P. A. AU - Koch, A. AU - Baban, A. AU - Tran, N. AU - Berkels, R. AU - Papewalis, C. AU - Schulze-Osthoff, K. AU - Knuefermann, P. AU - Zähringer, U. AU - Schumann, R. R. AU - Rettori, V. AU - McCann, S. M. AU - Bornstein, S. R. PY - 2006 DA - 2006// TI - Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0601527103 DO - 10.1073/pnas.0601527103 ID - Zacharowski2006 ER - TY - JOUR AU - Caso, J. R. AU - Pradillo, J. M. AU - Hurtado, O. AU - Leza, J. C. AU - Moro, M. A. AU - Lizasoain, I. PY - 2008 DA - 2008// TI - Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke JO - Stroke VL - 39 UR - https://doi.org/10.1161/STROKEAHA.107.498212 DO - 10.1161/STROKEAHA.107.498212 ID - Caso2008 ER - TY - JOUR AU - Gárate, I. AU - García-Bueno, B. AU - Madrigal, J. L. AU - Bravo, L. AU - Berrocoso, E. AU - Caso, J. R. AU - Micó, J. A. AU - Leza, J. C. PY - 2011 DA - 2011// TI - Origin and consequences of brain toll-like receptor 4 pathway stimulation in an experimental model of depression JO - J Neuroinflammation VL - 8 UR - https://doi.org/10.1186/1742-2094-8-151 DO - 10.1186/1742-2094-8-151 ID - Gárate2011 ER - TY - JOUR AU - Li, M. AU - Matsunaga, N. AU - Hazeki, K. AU - Nakamura, K. AU - Takashima, K. AU - Seya, T. AU - Hazeki, O. AU - Kitazaki, T. AU - Iizawa, Y. PY - 2006 DA - 2006// TI - A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling JO - Mol Pharmacol VL - 69 UR - https://doi.org/10.1124/mol.105.019695 DO - 10.1124/mol.105.019695 ID - Li2006 ER - TY - JOUR AU - Takashima, K. AU - Matsunaga, N. AU - Yoshimatsu, M. AU - Hazeki, K. AU - Kaisho, T. AU - Uekata, M. AU - Hazeki, O. AU - Akira, S. AU - Iizawa, Y. AU - Ii, M. PY - 2009 DA - 2009// TI - Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model JO - Br J Pharmacol VL - 157 UR - https://doi.org/10.1111/j.1476-5381.2009.00297.x DO - 10.1111/j.1476-5381.2009.00297.x ID - Takashima2009 ER - TY - JOUR AU - Kawamoto, T. AU - Ii, M. AU - Kitazaki, T. AU - Iizawa, Y. AU - Kimura, H. PY - 2008 DA - 2008// TI - TAK-242 selectively suppresses toll-like receptor 4-signaling mediated by the intracellular domain JO - Eur J Pharmacol VL - 584 UR - https://doi.org/10.1016/j.ejphar.2008.01.026 DO - 10.1016/j.ejphar.2008.01.026 ID - Kawamoto2008 ER - TY - JOUR AU - Matsunaga, N. AU - Tsuchimori, N. AU - Matsumoto, T. AU - Ii, M. PY - 2011 DA - 2011// TI - TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules JO - Mol Pharmacol VL - 79 UR - https://doi.org/10.1124/mol.110.068064 DO - 10.1124/mol.110.068064 ID - Matsunaga2011 ER - TY - JOUR AU - Yao, L. AU - Kan, E. M. AU - Lu, J. AU - Hao, A. AU - Dheen, S. T. AU - Kaur, C. AU - Ling, E. A. PY - 2013 DA - 2013// TI - Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia JO - J Neuroinflammation VL - 10 UR - https://doi.org/10.1186/1742-2094-10-23 DO - 10.1186/1742-2094-10-23 ID - Yao2013 ER - TY - JOUR AU - Ando, T. AU - Brown, R. F. AU - Berg, R. D. AU - Dunn, A. J. PY - 2000 DA - 2000// TI - Bacterial translocation can increase plasma corticosterone and brain catecholamine and indoleamine metabolism JO - Am J Physiol Regul Integr Comp Physiol VL - 279 ID - Ando2000 ER - TY - JOUR AU - Leza, J. C. AU - Salas, E. AU - Sawicki, G. AU - Russell, J. C. AU - Radomski, M. W. PY - 1998 DA - 1998// TI - The effects of stress on homeostasis in JCR-LA-cp rats: the role of nitric oxide JO - J Pharmacol Exp Ther VL - 286 ID - Leza1998 ER - TY - JOUR AU - Radley, J. J. AU - Arias, C. M. AU - Sawchenko, P. E. PY - 2006 DA - 2006// TI - Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress JO - J Neurosci VL - 26 UR - https://doi.org/10.1523/JNEUROSCI.4297-06.2006 DO - 10.1523/JNEUROSCI.4297-06.2006 ID - Radley2006 ER - TY - JOUR AU - Schreiber, E. AU - Matthias, P. AU - Muller, M. M. AU - Schaffner, W. PY - 1989 DA - 1989// TI - Rapid detection of octamer binding proteins with ‘;mini-extracts’, prepared from a small number of cells JO - Nucleic Acids Res VL - 17 UR - https://doi.org/10.1093/nar/17.15.6419 DO - 10.1093/nar/17.15.6419 ID - Schreiber1989 ER - TY - JOUR AU - Li, X. H. AU - Gong, J. P. AU - Tu, B. AU - Shi, Y. J. AU - Liu, C. A. PY - 2003 DA - 2003// TI - In vivo expression of lipopolysaccharide binding protein and its gene induced by endotoxin JO - Chin J Traumatol VL - 6 ID - Li2003 ER - TY - JOUR AU - Das, N. P. AU - Ratty, A. K. PY - 1987 DA - 1987// TI - Studies on the effects of the narcotic alkaloids, cocaine, morphine and codeine on nonenzymatic lipid peroxidation in rat brain mitochondria JO - Biochem Med Metab Biol VL - 37 ID - Das1987 ER - TY - JOUR AU - Bradford, M. M. PY - 1976 DA - 1976// TI - A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding JO - Anal Biochem VL - 72 UR - https://doi.org/10.1016/0003-2697(76)90527-3 DO - 10.1016/0003-2697(76)90527-3 ID - Bradford1976 ER - TY - JOUR AU - Gárate, I. AU - Garcia-Bueno, B. AU - Madrigal, J. L. AU - Caso, J. R. AU - Alou, L. AU - Gomez-Lus, M. L. AU - Micó, J. A. AU - Leza, J. C. PY - 2013 DA - 2013// TI - Stress-induced neuroinflammation: role of the toll-like receptor-4 pathway JO - Biol Psychiatry VL - 73 UR - https://doi.org/10.1016/j.biopsych.2012.07.005 DO - 10.1016/j.biopsych.2012.07.005 ID - Gárate2013 ER - TY - JOUR AU - Fukata, M. AU - Michelsen, K. S. AU - Eri, R. AU - Thomas, L. S. AU - Hu, B. AU - Lukasek, K. AU - Nast, C. C. AU - Lechago, J. AU - Xu, R. AU - Naiki, Y. AU - Soliman, A. AU - Arditi, M. AU - Abreu, M. T. PY - 2005 DA - 2005// TI - Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis JO - Am J Physiol Gastrointest Liver Physiol VL - 288 UR - https://doi.org/10.1152/ajpgi.00328.2004 DO - 10.1152/ajpgi.00328.2004 ID - Fukata2005 ER - TY - JOUR AU - Poltorak, A. AU - He, X. AU - Smirnova, I. AU - Liu, M. Y. AU - Van Huffel, C. AU - Du, X. AU - Birdwell, D. AU - Alejos, E. AU - Silva, M. AU - Galanos, C. AU - Freudenberg, M. AU - Ricciardi-Castagnoli, P. AU - Layton, B. AU - Beutler, B. PY - 1998 DA - 1998// TI - Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene JO - Science VL - 282 UR - https://doi.org/10.1126/science.282.5396.2085 DO - 10.1126/science.282.5396.2085 ID - Poltorak1998 ER - TY - JOUR AU - Makkouk, A. AU - Abdelnoor, A. M. PY - 2009 DA - 2009// TI - The potential use of Toll-like receptor (TLR) agonists and antagonists as prophylactic and/or therapeutic agents JO - Immunopharmacol Immunotoxicol VL - 31 UR - https://doi.org/10.1080/08923970902802926 DO - 10.1080/08923970902802926 ID - Makkouk2009 ER - TY - JOUR AU - Tsan, M. F. AU - Gao, B. PY - 2004 DA - 2004// TI - Endogenous ligands of toll-like receptors JO - J Leukoc Biol VL - 76 UR - https://doi.org/10.1189/jlb.0304127 DO - 10.1189/jlb.0304127 ID - Tsan2004 ER - TY - JOUR AU - Fleshner, M. PY - 2013 DA - 2013// TI - Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome JO - Brain Behav Immun VL - 27 UR - https://doi.org/10.1016/j.bbi.2012.08.012 DO - 10.1016/j.bbi.2012.08.012 ID - Fleshner2013 ER - TY - JOUR AU - Moghaddam, B. PY - 1993 DA - 1993// TI - Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia JO - J Neurochem VL - 60 UR - https://doi.org/10.1111/j.1471-4159.1993.tb13387.x DO - 10.1111/j.1471-4159.1993.tb13387.x ID - Moghaddam1993 ER - TY - JOUR AU - Glezer, I. AU - Zekki, H. AU - Scavone, C. AU - Rivest, S. PY - 2003 DA - 2003// TI - Modulation of the innate immune response by NMDA receptors has neuropathological consequences JO - J Neurosci VL - 23 ID - Glezer2003 ER - TY - JOUR AU - Kizaki, T. AU - Izawa, T. AU - Sakurai, T. AU - Haga, S. AU - Taniguchi, N. AU - Tajiri, H. AU - Watanabe, K. AU - Day, N. K. AU - Toba, K. AU - Ohno, H. PY - 2008 DA - 2008// TI - Beta2-adrenergic receptor regulates toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2 JO - Immunology VL - 124 UR - https://doi.org/10.1111/j.1365-2567.2007.02781.x DO - 10.1111/j.1365-2567.2007.02781.x ID - Kizaki2008 ER - TY - JOUR AU - Chaniotou, Z. AU - Giannogonas, P. AU - Theoharis, S. AU - Teli, T. AU - Gay, J. AU - Savidge, T. AU - Koutmani, Y. AU - Brugni, J. AU - Kokkotou, E. AU - Pothoulakis, C. AU - Karalis, K. P. PY - 2010 DA - 2010// TI - Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis JO - Gastroenterology VL - 139 UR - https://doi.org/10.1053/j.gastro.2010.08.024 DO - 10.1053/j.gastro.2010.08.024 ID - Chaniotou2010 ER - TY - JOUR AU - Laflamme, N. AU - Rivest, S. PY - 2001 DA - 2001// TI - Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components JO - FASEB J VL - 15 UR - https://doi.org/10.1096/fj.00-0339com DO - 10.1096/fj.00-0339com ID - Laflamme2001 ER - TY - JOUR AU - Lehnardt, S. AU - Lachance, C. AU - Patrizi, S. AU - Lefebvre, S. AU - Follett, P. L. AU - Jensen, F. E. AU - Rosenberg, P. A. AU - Volpe, J. J. AU - Vartanian, T. PY - 2002 DA - 2002// TI - The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS JO - J Neurosci VL - 22 ID - Lehnardt2002 ER - TY - JOUR AU - Zhang, Y. AU - Woodruff, M. AU - Zhang, Y. AU - Miao, J. AU - Hanley, G. AU - Stuart, C. AU - Zeng, X. AU - Prabhakar, S. AU - Moorman, J. AU - Zhao, B. AU - Yin, D. PY - 2008 DA - 2008// TI - Toll-like receptor 4 mediates chronic restraint stress-induced immune suppression JO - J Neuroimmunol VL - 194 UR - https://doi.org/10.1016/j.jneuroim.2007.12.002 DO - 10.1016/j.jneuroim.2007.12.002 ID - Zhang2008 ER - TY - JOUR AU - Wang, R. P. AU - Yao, Q. AU - Xiao, Y. B. AU - Zhu, S. B. AU - Yang, L. AU - Feng, J. M. AU - Li, D. Z. AU - Li, X. L. AU - Wu, J. J. AU - Chen, J. PY - 2011 DA - 2011// TI - Toll-like receptor 4/nuclear factor-kappa B pathway is involved in myocardial injury in a rat chronic stress model JO - Stress VL - 14 UR - https://doi.org/10.3109/10253890.2011.571729 DO - 10.3109/10253890.2011.571729 ID - Wang2011 ER - TY - JOUR AU - Tang, S. C. AU - Arumugam, T. V. AU - Xu, X. AU - Cheng, A. AU - Mughal, M. R. AU - Jo, D. G. AU - Lathia, J. D. AU - Siler, D. A. AU - Chigurupati, S. AU - Ouyang, X. AU - Magnus, T. AU - Camandola, S. AU - Mattson, M. P. PY - 2007 DA - 2007// TI - Pivotal role for neuronal toll-like receptors in ischemic brain injury and functional deficits JO - Proc Natl Acad Sci U S A VL - 104 UR - https://doi.org/10.1073/pnas.0702553104 DO - 10.1073/pnas.0702553104 ID - Tang2007 ER - TY - JOUR AU - Okun, E. AU - Barak, B. AU - Saada-Madar, R. AU - Rothman, S. M. AU - Griffioen, K. J. AU - Roberts, N. AU - Castro, K. AU - Mughal, M. R. AU - Pita, M. A. AU - Stranahan, A. M. AU - Arumugam, T. V. AU - Mattson, M. P. PY - 2012 DA - 2012// TI - Evidence for a developmental role for TLR4 in learning and memory JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0047522 DO - 10.1371/journal.pone.0047522 ID - Okun2012 ER - TY - JOUR AU - Olson, J. K. AU - Miller, S. D. PY - 2004 DA - 2004// TI - Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs JO - J Immunol VL - 173 UR - https://doi.org/10.4049/jimmunol.173.6.3916 DO - 10.4049/jimmunol.173.6.3916 ID - Olson2004 ER - TY - JOUR AU - Kilic, U. AU - Kilic, E. AU - Matter, C. M. AU - Bassetti, C. L. AU - Hermann, D. M. PY - 2008 DA - 2008// TI - TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration JO - Neurobiol Dis VL - 31 UR - https://doi.org/10.1016/j.nbd.2008.03.002 DO - 10.1016/j.nbd.2008.03.002 ID - Kilic2008 ER - TY - JOUR AU - Sha, T. AU - Sunamoto, M. AU - Kitazaki, T. AU - Sato, J. AU - Ii, M. AU - Iizawa, Y. PY - 2007 DA - 2007// TI - Therapeutic effects of TAK-242, a novel selective toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model JO - Eur J Pharmacol VL - 571 UR - https://doi.org/10.1016/j.ejphar.2007.06.027 DO - 10.1016/j.ejphar.2007.06.027 ID - Sha2007 ER - TY - JOUR AU - Sha, T. AU - Iizawa, Y. AU - Ii, M. PY - 2011 DA - 2011// TI - Combination of imipenem and TAK-242, a toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis JO - Shock VL - 35 UR - https://doi.org/10.1097/SHK.0b013e3181f48942 DO - 10.1097/SHK.0b013e3181f48942 ID - Sha2011 ER - TY - CHAP AU - Wittebole, X. AU - Castanares-Zapatero, D. AU - Laterre, P. F. PY - 2010 DA - 2010// TI - Toll-like receptor 4 modulation as a strategy to treat sepsis BT - Mediators Inflamm ID - Wittebole2010 ER - TY - JOUR AU - Rice, T. W. AU - Wheeler, A. P. AU - Bernard, G. R. AU - Vincent, J. L. AU - Angus, D. C. AU - Aikawa, N. AU - Demeyer, I. AU - Sainati, S. AU - Amlot, N. AU - Cao, C. AU - Ii, M. AU - Matsuda, H. AU - Mouri, K. AU - Cohen, J. PY - 2010 DA - 2010// TI - A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis JO - Crit Care Med VL - 38 UR - https://doi.org/10.1097/CCM.0b013e3181e7c5c9 DO - 10.1097/CCM.0b013e3181e7c5c9 ID - Rice2010 ER - TY - CHAP AU - Griffiths, M. R. AU - Gasque, P. AU - Neal, J. W. PY - 2010 DA - 2010// TI - The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review BT - Int J Inflam ID - Griffiths2010 ER - TY - JOUR AU - Kigerl, K. A. AU - Lai, W. AU - Rivest, S. AU - Hart, R. P. AU - Satoskar, A. R. AU - Popovich, P. G. PY - 2007 DA - 2007// TI - Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury JO - J Neurochem VL - 102 UR - https://doi.org/10.1111/j.1471-4159.2007.04524.x DO - 10.1111/j.1471-4159.2007.04524.x ID - Kigerl2007 ER - TY - JOUR AU - Romanovsky, A. A. AU - Steiner, A. A. AU - Matsumura, K. PY - 2006 DA - 2006// TI - Cells that trigger fever JO - Cell Cycle VL - 5 UR - https://doi.org/10.4161/cc.5.19.3321 DO - 10.4161/cc.5.19.3321 ID - Romanovsky2006 ER -