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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress

Figure 5

Toll-like receptor-4 upregulation is elicited by acute restraint stress exposure in rat brain frontal cortex. Protein levels of (A) toll-like receptor (TLR)-4, (C) myeloid differentiation protein-2 (MD2) and (E) myeloid differentiation factor 88 (MyD88) in brain frontal cortex samples of control (CONTROL) and stressed rats with (S(TAK)) or without (STRESS) TAK-242. The densitometric data of the respective band of interest are normalized by β-actin (lower band). Data are representative of two experiments (n = 3 per group in each experiment). O.D., optical density. mRNA relative levels of (B) TLR-4, (D) MD2 and (F) MyD88 in brain frontal cortex samples of control and stressed rats with or without TAK-242 (S(TAK) or STRESS, respectively). mRNA data are normalized by tubulin. Data represent the mean ± SEM (n = 4 to 5 per group). One-way analysis of variance followed by Newman–Keuls post hoc test. *P < 0.05 versus control; # P < 0.05 versus stress. ## P < 0.01 versus stress. This statistical data can be used for A and B.

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