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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress

Figure 6

TAK-242 effects on NF-κB signalling under control and stress conditions. (A) Transcriptional activity of NF-κB p65 subunit in nuclear extracts of control (CONTROL) and stressed rats with TAK-242 (S(TAK)) or without TAK-242 (STRESS). The data represent the mean ± SEM (n = 5 per group). One-way analysis of variance followed by Newman–Keuls post hoc test. A.U., arbitrary units. (B) IκBα mRNA relative levels in brain frontal cortex samples from control and stressed rats with or without TAK-242 (S(TAK) and STRESS, respectively). mRNA data are normalized by tubulin. Data represent the mean ± SEM (n = 5 to 6 per group). One-way analysis of variance followed by Newman–Keuls post hoc test. versus control *P < 0.05 ; # P < 0.05 versus stress.

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