Figure 3
Progression of oxidative stress in the hippocampus and neocortex of APP SL transgenic mice over age. Lipid peroxidation is shown as TBARS levels per mg protein in the hippocampus (A) and neocortex (B) of 4, 6, 9, and 12-month-old APPSL mice. n = 18/group. All data were analyzed by two way ANOVA followed by Bonferroni’s post hoc test. * significances between genotypes. + significances between age groups of APPSL transgenic mice. *P <0.05; **P <0.01; ***P <0.001. Abbreviations: TBARS: thiobarbituric acid reactive substances, analysis of variance: ANOVA, Amyloid Precursor protein carrying the Swedish London mutation: APPSL, probability: P.