Intermittent fasting (IF) prevents lipopolysaccharide (LPS)-induced memory impairment in the Barnes maze and inhibitory avoidance task. (A) Barnes maze test results (***P < 0.001 versus IF and IF + LPS groups). Data are represented as the escape latency (time in seconds that the rat takes to find the correct hole containing the burrow). (B) Inhibitory avoidance test results (*P < 0.05 IF test session versus its training session; **P < 0.01 Control test session versus its training session; ***P < 0.001 IF + LPS test session versus its training session; #P < 0.05 IF + LPS versus LPS test sessions). Both tests showed that IF attenuated memory impairment elicited by LPS challenge. (C) Beginning 24 hours after LPS injection, mice were tested daily for motor performance on a rotarod. The latency to fall during the testing period (four days) are shown. (D, E) Results of the analysis of spontaneous locomotor activity in the electronic animal activity meter showing the total locomotion (D) and total rearing (E) 24 hours after LPS administration. N = 8 to 10 for each experimental group.