Figure 1
From: Heat shock protein 60: an endogenous inducer of dopaminergic cell death in Parkinson disease
Hsp60 mRNA expression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice and Parkinson disease (PD) patients. (A) Hsp60 mRNA expression in the mesencephalon (substantia nigra (SN), filled circles) and the striatum (open circles) of C57/BL6 mice treated with MPTP. Mice (n = 8 to 10 per group) were treated using the acute MPTP paradigm (4 × 20 mg/kg MPTP-HCl (Sigma-Aldrich, Lyon, France) every 2 hours) and animals were killed 12, 24, 48, 96 or 168 hours after the last injection. (B) Hsp60/TH mRNA ratios in the SN of PD patients and aged-matched subjects. Results were expressed as a ratio to correct for dopaminergic (DA) cell loss in PD. *P < 0.05 versus corresponding controls.