Figure 5

Systemic lipopolysaccharide (LPS) induced apoptosis in retina. A. TUNEL staining of retinal cross-sections from P7 rats indicated an increased number of apoptotic cells, most of which were located in the inner retinal layer, especially in the ganglion cell layer. Original magnification 400×. B. The thickness of inner retina relative to outer retina was significantly decreased in the LPS-treated P14 rats. C. Flow cytometry showed that the percentage of PI⁺Annexin⁺ cells indicating apoptotic cells were significantly increased in the retina of the LPS-treated P7 rats. *P <0.05; **P <0.01; ns, not significant.