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Table 1 Arterial pH, blood gases, glucose, and lactate levels

From: Synergistic white matter protection with acute-on-chronic endotoxin and subsequent asphyxia in preterm fetal sheep

 

Group

-24 h

Day 1

Day 1 + 6 h

Day 2

Day 3

Day 3 + 6 h

Day 4 + 6 h

Day 5 + 6 h

Day 6

pH

S-S

7.38 ± 0.00

7.37 ± 0.01

7.37 ± 0.00

7.36 ± 0.00

7.36 ± 0.01

7.36 ± 0.00

7.35 ± 0.01

7.35 ± 0.01

7.35 ± 0.01

 

L-S

7.38 ± 0.00

7.38 ± 0.00

7.38 ± 0.00

7.38 ± 0.00

7.38 ± 0.00

7.34 ± 0.00

7.36 ± 0.00

7.36 ± 0.00

7.35 ± 0.00

 

S-A

7.36 ± 0.00

7.37 ± 0.00

7.36 ± 0.00

7.37 ± 0.00

7.36 ± 0.00

7.37 ± 0.00

7.36 ± 0.00

7.36 ± 0.01

7.36 ± 0.00

 

L-A

7.37 ± 0.00

7.37 ± 0.00

7.37 ± 0.00

7.36 ± 0.00

7.36 ± 0.00

7.37 ± 0.00

7.38 ± 0.00*#

7.37 ± 0.00

7.35 ± 0.01

paCO 2 (mmHg)

S-S

45.4 ± 1.4

49.5 ± 0.8

49.6 ± 1.1

50.1 ± 1.0

50.1 ± 1.5

48.3 ± 1.1

49.3 ± 1.2

50.0 ± 2.0

48.3 ± 1.4

 

L-S

43.9 ± 1.6

49.2 ± 1.6

48.7 ± 1.0

49.2 ± 1.5

48.9 ± 1.1

54.8 ± 2.1

50.7 ± 1.6

48.5 ± 1.4

49.1 ± 1.1

 

S-A

43.5 ± 1.5

46.5 ± 1.2

47.7 ± 1.0

50.0 ± 1.3

48.5 ± 0.9

49.2 ± 0.8

48.3 ± 1.0

46.0 ± 1.0

47.8 ± 1.7

 

L-A

42.6 ± 1.1

46.6 ± 1.3

46.2 ± 1.6

48.0 ± 1.7

48.2 ± 1.5

49.3 ± 1.8

46.5 ± 1.2#

43.9 ± 1.6*#

47.4 ± 1.5

paO 2 (mmHg)

S-S

24.6 ± 1.2

25.2 ± 1.5

24.0 ± 1.6

24.6 ± 2.3

26.3 ± 2.4

23.2 ± 2.9

24.3 ± 3.2

24.7 ± 2.6

25.3 ± 2.3

 

L-S

26.4 ± 1.2

26.0 ± 1.7

25.4 ± 1.4

25.9 ± 1.7

25.0 ± 2.0

21.4 ± 1.6

24.2 ± 2.7

25.9 ± 2.5

24.7 ± 1.9

 

S-A

25.6 ± 0.8

24.9 ± 1.5

24.7 ± 1.3

24.3 ± 1.5

24.1 ± 1.7

24.3 ± 1.8

24.3 ± 1.4

26.2 ± 1.3

25.3 ± 1.1

 

L-A

27.2 ± 0.8

25.4 ± 0.7

24.6 ± 1.0

26.2 ± 0.9

25.3 ± 0.8

22.6 ± 0.8

21.3 ± 1.3

24.2 ± 1.30

27.6 ± 1.6

Lactate (mmol/L)

S-S

0.8 ± 0.1

0.8 ± 0.1

0.8 ± 0.1

0.8 ± 0.0

0.8 ± 0.06

0.81 ± 0.1

0.8 ± 0.1

0.9 ± 0.1

0.8 ± 0.1

 

L-S

0.7 ± 0.1

0.7 ± 0.1

0.7 ± 0.0

0.7 ± 0.0

0.8 ± 0.08

1.50 ± 0.2

1.5 ± 0.4*

0.7 ± 0.0

0.6 ± 0.1

 

S-A

0.8 ± 0.1

0.8 ± 0.1

0.9 ± 0.1

0.9 ± 0.1

0.9 ± 0.13

1.1 ± 0.16

0.9 ± 0.1#

2.2 ± 0.4*#

0.8 ± 0.1

 

L-A

0.6 ± 0.1

0.6 ± 0.1

0.7 ± 0.1

0.7 ± 0.1

0.7 ± 0.05

1.1 ± 0.31

0.8 ± 0.1

1.8 ± 0.4#

0.7 ± 0.1

Glucose (mmol/L)

S-S

0.8 ± 0.1

1.1 ± 0.1

1.2 ± 0.1

1.3 ± 0.1

1.2 ± 0.1

1.3 ± 0.1

1.2 ± 0.1

1.2 ± 0.1

1.2 ± 0.1

 

L-S

0.8 ± 0.1

0.8 ± 0.1

0.9 ± 0.1

1.0 ± 0.1*

1.1 ± 0.1

0.9 ± 0.1*

1.0 ± 0.1

1.0 ± 0.1

0.9 ± 0.1

 

S-A

1.0 ± 0.1

0.9 ± 0.1

1.2 ± 0.1

1.1 ± 0.1*

1.1 ± 0.0

1.3 ± 0.1#

1.2 ± 0.1

1.5 ± 0.1*

1.0 ± 0.1

 

L-A

0.8 ± 0.1

1.0 ± 0.2

0.9 ± 0.1

1.1 ± 0.1*

1.1 ± 0.1

0.8 ± 0.1*§

1.0 ± 0.1

1.2 ± 0.1

1.1 ± 0.1

  1. S-S = Sal-Sham (saline infusion + saline boluses + sham occlusion); L-S = LPS-Sham (LPS infusion + LPS boluses + sham occlusion); S-A = Sal-Asp (saline infusion + saline boluses + 15 minutes of umbilical cord occlusion); L-A = LPS-Asp (LPS infusion + LPS boluses + 15 minutes of umbilical cord occlusion). Saline or LPS infusions were started on day 1; boluses of saline or LPS were given on days 3, 4 and 5. Data during and after umbilical cord occlusion performed on day 5, 4 hours after the last LPS or saline bolus, are shown in Table 2. The chronic low-dose LPS or saline infusion continued from time zero to the end of day 5. Days 7 to 10 are not shown as there were no differences between groups at those times. LPS, lipopolysaccharide; paCO2, fetal arterial pressure of CO2 (mmHg); paO2, fetal arterial pressure of oxygen (mmHg). * P <0.05 versus Sal-Sham, # P <0.05 versus LPS-Sham, § P <0.05 versus Sal-Asp. Data are mean ± SEM.