| Group | -24 h | Day 1 | Day 1 + 6 h | Day 2 | Day 3 | Day 3 + 6 h | Day 4 + 6 h | Day 5 + 6 h | Day 6 |
---|---|---|---|---|---|---|---|---|---|---|
pH | S-S | 7.38 ± 0.00 | 7.37 ± 0.01 | 7.37 ± 0.00 | 7.36 ± 0.00 | 7.36 ± 0.01 | 7.36 ± 0.00 | 7.35 ± 0.01 | 7.35 ± 0.01 | 7.35 ± 0.01 |
 | L-S | 7.38 ± 0.00 | 7.38 ± 0.00 | 7.38 ± 0.00 | 7.38 ± 0.00 | 7.38 ± 0.00 | 7.34 ± 0.00 | 7.36 ± 0.00 | 7.36 ± 0.00 | 7.35 ± 0.00 |
 | S-A | 7.36 ± 0.00 | 7.37 ± 0.00 | 7.36 ± 0.00 | 7.37 ± 0.00 | 7.36 ± 0.00 | 7.37 ± 0.00 | 7.36 ± 0.00 | 7.36 ± 0.01 | 7.36 ± 0.00 |
 | L-A | 7.37 ± 0.00 | 7.37 ± 0.00 | 7.37 ± 0.00 | 7.36 ± 0.00 | 7.36 ± 0.00 | 7.37 ± 0.00 | 7.38 ± 0.00*# | 7.37 ± 0.00 | 7.35 ± 0.01 |
paCO 2 (mmHg) | S-S | 45.4 ± 1.4 | 49.5 ± 0.8 | 49.6 ± 1.1 | 50.1 ± 1.0 | 50.1 ± 1.5 | 48.3 ± 1.1 | 49.3 ± 1.2 | 50.0 ± 2.0 | 48.3 ± 1.4 |
 | L-S | 43.9 ± 1.6 | 49.2 ± 1.6 | 48.7 ± 1.0 | 49.2 ± 1.5 | 48.9 ± 1.1 | 54.8 ± 2.1 | 50.7 ± 1.6 | 48.5 ± 1.4 | 49.1 ± 1.1 |
 | S-A | 43.5 ± 1.5 | 46.5 ± 1.2 | 47.7 ± 1.0 | 50.0 ± 1.3 | 48.5 ± 0.9 | 49.2 ± 0.8 | 48.3 ± 1.0 | 46.0 ± 1.0 | 47.8 ± 1.7 |
 | L-A | 42.6 ± 1.1 | 46.6 ± 1.3 | 46.2 ± 1.6 | 48.0 ± 1.7 | 48.2 ± 1.5 | 49.3 ± 1.8 | 46.5 ± 1.2# | 43.9 ± 1.6*# | 47.4 ± 1.5 |
paO 2 (mmHg) | S-S | 24.6 ± 1.2 | 25.2 ± 1.5 | 24.0 ± 1.6 | 24.6 ± 2.3 | 26.3 ± 2.4 | 23.2 ± 2.9 | 24.3 ± 3.2 | 24.7 ± 2.6 | 25.3 ± 2.3 |
 | L-S | 26.4 ± 1.2 | 26.0 ± 1.7 | 25.4 ± 1.4 | 25.9 ± 1.7 | 25.0 ± 2.0 | 21.4 ± 1.6 | 24.2 ± 2.7 | 25.9 ± 2.5 | 24.7 ± 1.9 |
 | S-A | 25.6 ± 0.8 | 24.9 ± 1.5 | 24.7 ± 1.3 | 24.3 ± 1.5 | 24.1 ± 1.7 | 24.3 ± 1.8 | 24.3 ± 1.4 | 26.2 ± 1.3 | 25.3 ± 1.1 |
 | L-A | 27.2 ± 0.8 | 25.4 ± 0.7 | 24.6 ± 1.0 | 26.2 ± 0.9 | 25.3 ± 0.8 | 22.6 ± 0.8 | 21.3 ± 1.3 | 24.2 ± 1.30 | 27.6 ± 1.6 |
Lactate (mmol/L) | S-S | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.0 | 0.8 ± 0.06 | 0.81 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 |
 | L-S | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.0 | 0.7 ± 0.0 | 0.8 ± 0.08 | 1.50 ± 0.2 | 1.5 ± 0.4* | 0.7 ± 0.0 | 0.6 ± 0.1 |
 | S-A | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.13 | 1.1 ± 0.16 | 0.9 ± 0.1# | 2.2 ± 0.4*# | 0.8 ± 0.1 |
 | L-A | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.05 | 1.1 ± 0.31 | 0.8 ± 0.1 | 1.8 ± 0.4# | 0.7 ± 0.1 |
Glucose (mmol/L) | S-S | 0.8 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.2 ± 0.1 |
 | L-S | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1* | 1.1 ± 0.1 | 0.9 ± 0.1* | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 |
 | S-A | 1.0 ± 0.1 | 0.9 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1* | 1.1 ± 0.0 | 1.3 ± 0.1# | 1.2 ± 0.1 | 1.5 ± 0.1* | 1.0 ± 0.1 |
 | L-A | 0.8 ± 0.1 | 1.0 ± 0.2 | 0.9 ± 0.1 | 1.1 ± 0.1* | 1.1 ± 0.1 | 0.8 ± 0.1*§ | 1.0 ± 0.1 | 1.2 ± 0.1 | 1.1 ± 0.1 |